I'm not a pro on this subject, but I would assume they are comprable. Where the discrepancy may occur is if you need to make subsequent calls using the response from the previous call.
In Webstudio you make many API calls on the same page, but they can't rely on the response from the previous call.
So for notion pages for example this is problematic (see more here
https://docs.webstudio.is/university/integrations/notion#use-notion-databases-not-notion-pages). Even if webstudio did support making subsequent api calls, it would be bad for performance because you call 1 then use that data to call 2 and so forth each waiting for the previous to finish.
Most platforms will give you what you need in one call though